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For people with type 2 diabetes, insulin and sulfonylureas carry an additional risk of hypoglycaemia if used alongside retatrutide, and dose adjustments should only be made under close clinical supervision

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FIGURE 6 Plasma insulin levels sampled from the tail tended to rise from baseline about 60 min after application of semaglutide either i.v

GLP-1 agonists trigger the pancreas to release insulin, lowering the amount of glucose (sugar) in the blood

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It even suggests these treatments might reduce long-term risks by improving metabolic health and controlling inflammation