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These findings underscore the central mediating role of the mTOR pathway in acupuncture-induced regulation of autophagy and synaptic repair

A drug might have a compound patent expiring in Year 10, an NCE exclusivity running to Year 5, formulation patents running to Year 14, and pediatric exclusivity adding six months to everything producing an effective exclusivity window that extends to Year 14.5, despite a nominal compound patent expiry in Year 10

Reference: Systematic Review BPC-157 in Orthopaedic Sports Medicine (2024)

Importantly, multiple agent therapy of a low dose of each of sildenafil and PT-141 appeared to result in a thereapeutic benefit equivalent to a pharmacologically active higher dose of either agent as monotherapy, without the attendant adverse events associated with higher dose monotherapy

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Thirupathi, A