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Regulatory Concerns: The sale of these peptides for research purposes solely, rather than for human consumption, raises regulatory concerns in many nations

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MacFabe DF, Rodrguez-Capote K, Hoffman JE

What strikes me most about tirzepatide specifically is the dual GIP/GLP-1 mechanism

Indeed, patients with T1DM (98) and mouse models of beta-cell destruction (99) report that insulin deficiency is accompanied by an increase in alpha-cell mass, which has served as rationale for the notion that a loss of beta-cell paracrine signaling drives alpha-cell proliferation

Only statistically significant results are presented in the main text, while non-significant findings are reported in Supplementary information