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The slices were transferred to a recording chamber and superfused constantly with carbogen (95% O 2 /5% CO 2 )-bubbled Ames medium (Sigma-Aldrich, Inc., St

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A patient with a low-responder GLP1R variant might pay $249 monthly for compounded tirzepatide but experience minimal weight loss, while a genetically-matched microdose patient at $129 per month may lose 23 pounds weekly