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SARS-CoV-2 could invade blood vessels, induce vascular damage, and activate systemic thrombotic events with severe to fatal coagulopathies in COVID-19 patients 100

Turpin W, Lee SH, Raygoza Garay JA, Madsen KL, Meddings JB, Bedrani L, Power N, Espin-Garcia O, Xu W, Smith MI, Griffiths AM, Moayyedi P, Turner D, Seidman EG, Steinhart AH, Marshall JK, Jacobson K, Mack D, Huynh H, Bernstein CN, Paterson AD, Croitoru K, Crohns and Colitis Canada Genetic Environmental Microbial Project Research Consortium

doi: 10.1038/s41420-021-00709-4 29 YeLFChaudharyKRZandkarimiFHarkenADKinslowCJUpadhyayulaPSet al

Our model simulations are reflective of the hepatic GSH environment, agreeing with the supra-pharmacological concentrations of doxorubicin required to illicit comparable GSH depletion in the liver 39

Levey, H

Antioxidant Protection As weve established, glutathione is a potent antioxidant