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TSA confirmed that enough patients were randomized and again no association of the medications and pancreatic cancer was observed considering a NNH of 1000 and the short mean follow-up of the included trials (1.7 years)

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This leads to impaired bacterial clearance and contributes to the immunosuppressive state of sepsis, while mice lacking IRAK3 exhibited improved host defense and survival (Xie et al., 2021)