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Your body produces it on its own, but production declines significantly with age, from roughly 200 ng/mL at age 20 to around 80 ng/mL by age 60

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In this respect, enteric -syn accumulation could promote neurogenic immune/inflammatory responses, which impair intestinal barrier integrity and permeability and decrease tight junction protein expression [84, 85]

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FIGURE 8 The aforementioned abnormalities at the molecular level (downregulation of the Nrf2/HO-1 axis and GPX4) and subcellular structural level (neuronal somata and mitochondrial impairment) were consistent with the GSH metabolism perturbations identified by multi-omics analyses, collectively reflecting oxidative stress-associated damage in the hippocampus during SAE

Maintain a balanced diet rich in antioxidants, prioritize adequate sleep, stay hydrated, and manage stress levels