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"There will be a small proportion of people, 10% maximum, that are able to maintain [all] the weight they've lost," says Alex Miras, a clinical professor of medicine at Ulster University
Lancet 330(8571):13001304 Kushner RF, Calanna S, Davies M, Dicker D, Garvey WT, Goldman B et al (2020) Semaglutide 2.4 mg for the treatment of obesity: key elements of the STEP trials 1 to 5
However, the drug does not have Food And Drug Administration (FDA) approval for this purpose
Reviewed February 2026
Subsequently, PKA activity can augment the release of neurotransmitters into the synapse, facilitating long-term potentiation (LTP) and promoting cAMP-response element binding protein (CREB) phosphorylation, supporting cell growth/survival as well as synaptic plasticity [31, 33]