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These effects disappear when the intervention stops regardless of pharmacological activity

The mechanism of action of PT-141 is independent of nitric oxide signaling pathways and peripheral vascular mechanisms, offering an alternative treatment modality for these patients

doi: 10.1007/s00726-008-0093-y

Hoogendijk et al., 1995

Jeanette M

GLP-1RA therapy, when prolonged and potent, may lead to a form of iatrogenic ERM : Short-term gains: lower glucose, lower weight, lower cardiovascular risk Long-term risks: impaired amino-acid balance, reduced re-anabolism, muscle loss, frailty, diminished resilience This progression can be subtle and clinically silentbiochemically detectable long before symptoms appear