Scenario 2: Want next pregnancy in 12-18 months Shortened treatment course necessary
Slowing titration to maintain energy and quality of life produces better long-term outcomes than pushing through severe fatigue, which often leads to treatment abandonment
The first patient, treated in 1906, was a 50 year old dying man who had just had his toe amputated due to gangrene from diabetes and was in a diabetic coma
Mean body weights decreases of 12.7% over placebo were seen after 68 weeks in Rybelsus treated patients
Potential explanations include differences in the type of patients included, adherence to study treatment, sample size, duration of drug exposure, and GLP1 receptor activation with greater HbA1c reduction with longer-acting human GLP1-based analogs than with some short-acting exendin-4 analogs
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