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(2023) 256(3):e220111

Cell energy metabolism and hyaluronan synthesis

However, while our results corroborate the existence of GLP-1R-associated endosomal signalling, they also suggest that sustained GLP-1R signalling, as indicated by cumulative insulin secretion over pharmacologically relevant timescales, is actually greater with the ligand (exendin-4-C16) with a reduced tendency to recruit mini-G s to Rab5-positive endosomes

Improved Insulin Sensitivity : GLP-1 enhances the bodys insulin response, improving glucose control, which is beneficial for those with type 2 diabetes or insulin resistance

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