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Both drugs aim to minimize risks while maximizing benefits for weight and diabetes management, with ongoing studies refining their long-term safety profiles

On the other hand, in HF patients, cardiac energy metabolism is shifted from fatty acid oxidation to glucose, and carnitine insufficiency in the failing myocardium is caused by the leakage of carnitine through damaged cardiomyocyte membranes [4]

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Bile acid sequestrants: glucose-lowering mechanisms and efficacy in type 2 diabetes