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Dysregulation of HRG1 can lead to heme accumulation and pathologies associated with impaired recycling [17]

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It can be made from phosphatidylethanolamine (PE) by methylation of the ethanolamine moiety in a reaction catalyzed by phosphatidylethanolamine N-methyltransferase

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In addition to ECs, pericytes and astrocytes are also activated in response to peripheral inflammation, significantly impacting BBB permeability