10.3390/ijms232213886 269 WangY.WangM.FanK.LiT.YanT.WuB.et al (2018b)
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So we dont have that same sort of rigour, if you like, on just overall safety. The third safety question is legal, and the answer differs by jurisdiction: United States
66,549,550 In patients with PD, AD, and amyotrophic lateral sclerosis (ALS), there is a significant increase in the zinc content within the cerebrospinal fluid
Active cancer or history of malignancy Pregnancy or breastfeeding Known peptide allergies Athletes subject to anti-doping testing (WADA prohibited) Raynauds disease or phenomenon Cold urticaria (hives from cold) Uncontrolled hypertension Peripheral vascular disease Open wounds (for local application) Pregnancy Cardiovascular conditions Diabetes (especially with neuropathy) Current infections Immunosuppression Blood clotting disorders Quality control issues represent perhaps the greatest practical risk with BPC-157