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GLP 1 therapy is considered after full evaluation

The idea is supported by maintenance of functional GSH/GSSG levels by Sp in BSO and neurotoxin treated cells as compared to untreated ones which showed a significant decline in the antioxidant ratio probably, due to enhanced formation of glutathionequinones 43

This mechanism ensures that in the absence of oxidative stress or other stimuli, the expression of NRF2-dependent antioxidant genes is suppressed [88, 90]

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In the 700s AD, the almond tree was brought from Spain to California by Franciscan padres