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Numerous factors are responsible for AA, such as chemoradiotherapy, viral hepatitis, overexposure to pesticides and insecticides, certain drugs, exposure to chemicals, and in some rare pregnancy cases

However, it is important to take into account the possibility that binding of JWU-A021 to TRPA1 channels leads to membrane depolarization and action potential generation, thereby stimulating additional Ca 2+ influx through VDCCs

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Centella Asiatica Leaf Water (16.4%) rounds out the formula with soothing hydration and barrier strengthening , while Centella 3x Complex (Madecassic Acid, Asiaticoside, Asiatic Acid) calms irritation and supports skin repair

Biochemistry 57 , 827838 (2018)

It can help reduce redness, calm irritation, and restore the skin's barrier function