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GLP-1 is a hormone secreted by the intestines that helps regulate blood sugar levels

It is not for pharmaceutical, domestic, or any other applications

A key challenge in studying native GLP-1 is its extremely short in vivo half-life of approximately 12 minutes, owing to rapid inactivation by dipeptidyl peptidase-4 (DPP-4), which cleaves the N-terminal His-Ala dipeptide from GLP-1 to produce the inactive metabolite GLP-1(936)amide

An FDA-approved medication (brand name Vyleesi ) indicated for premenopausal women with hypoactive sexual desire disorder, PT-141 stimulates melanocortin receptors in the brain to enhance arousal and desire in both sexes

Wilding JPH, Batterham RL, Calanna S et al (2021) Once-weekly semaglutide in adults with overweight or obesity

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