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Substrate supplementation alone may have limited impact on the tightly regulated NO pathway

Results Liraglutide and GUB09-145 improve metabolic parameters in DIO mice Following 35 weeks of feeding, DIO mice showed significantly increased body weight (53.0 0.6 g, n = 45) compared to chow controls (32.1 0.2 g, n = 10, p 0.05) following treatment with vehicle, liraglutide or GUB09-145 as compared to baseline (Fig

Other original studies, such as those included in a recent systematic review, reported benefits with Semaglutide and dulaglutide [39]

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as a result, their post-operative long-term survival is poor [70]