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Patients with complex anatomy, including those who have previously undergone fundoplication surgery or the LINX reflux management system, should ensure their surgical history is factored into any procedural planning

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UK investigations typically include full blood count, serum B12, and holotranscobalamin (active B12) where available

This scientific uncertainty directly impacts commercial interest, as developing a drug for a fragmented and unpredictable subpopulation within an already rare disease is a high-risk investment

Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin added to ongoing pioglitazone pioglitazone therapy in patients with type 2 diabetes: a 24-week, multicenter, randomized, double-blind, placebo-controlled, parallel-group study

Eat slowly and chew thoroughly Eating slowly and chewing food well can reduce swallowing excess air and help prevent the stomach pressure which sometimes causes heartburn