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In clinical trials, Wegovy after 68 weeks with 2.5 mg injections provided an average weight loss of 33.66 pounds (14.9%) versus the placebo group at 5.7 pounds (2.4%)

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Semaglutide trials (SUSTAIN series) reported nausea in roughly 37% of participants at higher doses, while tirzepatide trials (SURMOUNT series) documented nausea in 2633% across dose tiers

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