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Rat full-thickness wounds (6mm diameter, 13-day study) treated with GHK showed 64.5% reduction in wound size compared to 45.6% for vehicle-treated and 28.2% for control group, accompanied by significantly lower TNF- and elastin-degrading MMPs
Meanwhile, GHK-CU peptide is of interest for its copper-binding properties, which may participate in metalloproteinase activity regulation and oxidative stress responses through copper-dependent antioxidant enzyme activation
While it is naturally produced in our cells, levels can fluctuate based on age, lifestyle, and environment
While animal studies consistently demonstrate beneficial effects across diverse injury models and tissue types, the absence of adequately powered, controlled human clinical trials prevents definitive conclusions about efficacy in human disease
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