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Why Mechanism Does Not Guarantee Clinical Results Mechanistic findings are useful for hypothesis-building, but clinical outcomes require human studies with defined populations, formulations, controls, durations, and endpoints

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Am J Hum Genet 58 : 3541

In vitro studies with HEK cells stably transfected with various UGT1A6 amino acid variants indicate that the UGT1A6 *2 genotype had a 60% higher glucuronidation activity than the UGT1A6*1 variant [21]

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Tissue Platinum Concentration and Tumor Response in NonSmall-Cell Lung Cancer