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European Journal of Clinical Pharmacology, 28 (5), 567-571

During the title and abstract screening, 31 non-clinical studies were excluded

A study showed that indoleamine 2,3-dioxygenase 1 (IDO1) promotes atherosclerosis by inhibiting IL-10 production, which activates a cAMP-dependent pathway and suppresses Erk1/2 phosphorylation, leading to increased plaque instability (120)

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