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The fundamental challenge lies in transdermal delivery of large peptide molecules

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Access this article Similar content being viewed by others Abbreviations -MSH: -Melanozyten-stimulierendes Hormon DAG: Deutsche Adipositas-Gesellschaft GIP: Glukoseabhngiges insulinotropes Polypeptid GIPR: Rezeptor des glukoseabhngigen insulinotropen Polypeptids GLP-1: Glukagonhnliches Peptid 1 HbA 1c : Hmoglobin A 1c HOMA-IR: Homeostatic Model Assessment for Insulin Resistance HWZ: Halbwertszeit MC4R: Melanokortin-4-Rezeptor POMC: Proopiomelanokortin T2DM: Diabetes mellitus Typ 2 WHO: Weltgesundheitsorganisation Literatur Brandt SJ, Kleinert M, Tschop MH et al (2018) Are peptide conjugates the golden therapy against obesity

Given the long half-life of these medications, the AGA does not support the premise that holding these medications for one week prior to the procedure will adequately prevent aspiration of any retained gastric contents due to GLP-1 slowing of stomach emptying