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Elsevier, 18

Development of GLP-1MK-801 To safely harness the weight-lowering properties of NMDA receptor antagonism, we developed a targeting approach based on the hypothesis that conjugation of MK-801 to a GLP-1 analogue through a chemically cleavable disulfide linker would enhance the therapeutic potential of NMDA receptor antagonism in appetite-regulating brain regions enriched for GLP-1 receptors, while mitigating the adverse effects related to the non-restricted actions of MK-801

DSIP From R750 Quick links Protocols Sleep Optimisation & Insomnia Treatment Dosage: 100300 mcg before bed (subcutaneous injection) Cycle: Continuous use for 46 weeks, followed by a 2-week break Administration: Best taken 3060 minutes before bedtime Stacking: With Melatonin for circadian rhythm regulation With Semax or Selank for stress and anxiety control With CJC-1295 & Ipamorelin for GH release and deep sleep improvement Expected Benefits: Faster sleep onset and reduced sleep latency Increased deep delta wave sleep (slow-wave sleep) No grogginess or next-day drowsiness 2

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Component concentrations: TB-500, BPC-157, KPV each at ~3.33 mg/mL

[DOI] [PMC free article] [PubMed] [Google Scholar] Song Y., Manson J.E., Buring J.E., Liu S