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While constipation is a common side effect, Bowel Obstruction or Ileus (where the gut stops moving entirely) is a rare but serious medical emergency associated with GLP-1 use

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Retatrutide's mechanism of action involves the stimulation of three crucial hormone receptors: GLP-1 (Glucagon-like peptide-1): Plays a key role in lowering blood sugar levels and promoting satiety, which helps reduce food intake

Int J Cancer 118(7):16531659 Puzianowska-Kuznicka M, Krystyniak A, Madej A et al (2002) Functionally impaired TR mutants are present in thyroid papillary cancer

2023 Jul;15(7):377-383