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Tirzepatide once weekly for the treatment of obesity in people with type 2 diabetes (SURMOUNT-2): A double-blind, randomised, multicentre, placebo-controlled, phase 3 trial

The analysis was conducted over a 40-year time horizon, with both costs and outcomes discounted at an annual rate of 3.5%

That creates a stacking effect where each meal adds to the distension from the previous one

[DOI] [PubMed] [Google Scholar] 74.Russo A

Patients deemed inappropriate for treatment receive explanations of clinical concerns and may receive recommendations for alternative weight management approaches including referral to specialists, suggestion of comprehensive lifestyle modification programs, or guidance toward addressing underlying medical conditions before reconsidering pharmacological intervention

Use a calorie calculator or speak to a dietitian to determine how many fewer calories you need to eat daily to achieve your weight loss goals