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Various rodent models manifesting PCOS-like traits can be induced through the administration of diverse drugs and szintetikus hormones, including androgens containing dihydrotestosterone (DHT), testosterone (T), and dehydroepiandrosterone (DHEA), estrogen, as well as aromatase inhibitors ( Furthermore, the utilization of a combination of antibiotics, comprising vancomycin hydrochloride, ampicillin sodium, neomycin sulfate, and metronidazole, has exhibited effectiveness in eliminating the indigenous gut microbiota of the host ( Thus, our investigation endeavored to make model of a pseudo germ-free PCOS mouse through the application of letrozole and antibiotics, with the aim of allowing insight into the gut microbiotas influence on the regulation of metabolic and reproductive phenotypes in mice with PCOS
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Pentadecapeptide BPC 157 enhances the growth hormone receptor expression in tendon fibroblasts Link : PubMed 25415472 Summary : In rat tendon fibroblasts, BPC-157 dose- and time-dependently increased growth hormone receptor expression, boosting cell proliferation (via MTT assay and PCNA) when combined with growth hormone, supporting tendon healing
