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However, emerging evidence suggests that OS and pro-inflammatory signaling may also contribute to MDD (Tuon et al., 2021)

GHK-Cu upregulates BDNF (brain-derived neurotrophic factor), NGF (nerve growth factor), and NT-3 (neurotrophin-3) expression

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Since beta-endorphins are expected to impede performance in tests of maximal aerobic or anaerobic capacity, it may also worsen the greater rates of perceived exertion (RPE) that patients with T1D experience (38)

In more severe cases oral forms of the same medications may be utilized