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Some patients report that taking oral semaglutide before bed (on an empty stomach, with 30 minutes before sleep) helps them sleep through mild nausea, though this approach requires careful timing to ensure no evening food or drink interferes

Structurally, semaglutide is similar to human GLP-1 but modified to resist degradation by enzymes such as dipeptidyl peptidase-4 (DPP-4), prolonging its biological activity and effectiveness in controlling blood glucose and reducing body weight

doi: 10.3389/fphar.2021.627533 Goldstein, A

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