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In addition, the deubiquitinating enzyme BAP1 can remove monoubiquitination at the lysine 119 site of histone H2A on the SLC7A11 promoter, thereby inhibiting SLC7A11 transcription, further reducing cystine uptake of cells and increasing ferroptosis sensitivity

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Cellular oxidative stress causes the dissociation of the complex, oligomerization of GSTP, and induction of the JNK pathway, resulting in apoptosis

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E2-RING Expansion of the NEDD8 Cascade Confers Specificity to Cullin Modification

Dysregulated Wnt/-catenin signaling confers resistance to cuproptosis in cancer cells