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The modulation of UCN1 and CART turnover via TRPA1-dependent mechanisms by alcohol and its metabolites in the EWcp, may in turn influence the function of alcohol-sensitive and reward-related downstream brain areas (VTA, CeA, DRN and LS) ultimately shaping alcohol consumption patterns 3,7,13 .This is supported by the continuous decline in alcohol preference over the time associated with a lower Ucn1 and Cartpt levels

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