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Characterising the genetic architecture of changes in adiposity during adulthood using electronic health records

[DOI] [PMC free article] [PubMed] [Google Scholar] 105

Nobody outside Eli Lilly knows for certain

"These GLP-1 drugs help our body regulate how much we're eating by essentially signaling to our brains that we're full, and they help to regulate blood sugar and slow digestion," said emergency medicine Dr

Mechanism of Action GLP-1 is an endogenous hormone secreted by the intestines in response to food intake

Published clinical research has characterised the compound in controlled trials: a Phase 2 obesity trial reported dose-dependent body-weight change in the study population (Jastreboff et al., 2023), and a separate Phase 2 trial investigated the GIP/GLP-1/glucagon agonist in people with type 2 diabetes (Rosenstock et al., 2023)