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N Engl J Med 2021;384(12):111324

Initiating a GLP-1 agent in a patient with an undiagnosed TSH abnormality or pre-existing hypoglycemia without that context carries meaningful clinical risk

Elevated intracellular levels of Acetyl-CoA can activate histone acetyltransferases (HATs), such as p300, which catalyze the acetylation of histone H3 at lysine 9 (H3K9ac) and lysine 27 (H3K27ac)

PloS One (2012) 7(7):e41831

Yes GLP-1 improves fat oxidation, mitochondrial function, insulin sensitivity, and metabolic flexibility