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The most common phase II drug-metabolizing enzymes are UDP-glucuronosyltransferases (UGTs), sulfotransferases (SULTs), N-acetyltransferases (NATs), glutathione S-transferases (GSTs), methyltransferases (thiopurine S-methyltransferases (TPMTs), catechol O-methyltransferases (COMTs)) and acyltransferases (Jancova et al., 2010

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PMID: 12200686

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As such, we have selected 400 mg orally (pure form) once daily as the dose and route for this phase II trial