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The procognitive activity of Dihexa was evaluated in the Morris water maze task using the scopolamine-induced cognitive deficit model in young rats and also in aged rats

published in Frontiers in Physiology confirmed that BPC-157 dose- and time-dependently increased GHR expression in isolated rat Achilles tendon fibroblasts at both mRNA and protein level, and that GH added to BPC-157-treated fibroblasts produced significant, dose-dependent increases in cell proliferation establishing GHR upregulation as a specific molecular mechanism through which BPC-157 enhances local tissue sensitivity to growth hormone signalling

The cardiovascular impact via TMAO needs larger and longer human trials

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