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Tome-Carneiro J, Larrosa M, Yanez-Gascon MJ, et al

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If nausea lingers or worsens, talk to your doctor about possible adjustments to your plan, such as reducing your dose or exploring other potential treatments

Previously, the ACHIEVE-1 study evaluated orforglipron monotherapy in people with early type 2 diabetes uncontrolled with lifestyle intervention, and demonstrated a 12 mmol/mol (1.1%) greater HbA 1c reduction and a 5.9% greater body weight reduction than placebo (Rosenstock et al, 2025)

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Accordingly, GPx1-KO mice had significantly lower intestinal GPx activity than the wild-type mice before exposure to -irradiation