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Numerous studies have investigated this question, and the results are consistent: weight often returns once treatment is stopped

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Starting at a lower initial dose (for example, 2 mg instead of 4 mg) also helped partially reduce these GI symptoms, andas with other GLP-1 medicationsthe dose was gradually increased over time to improve tolerability

Zhang Y, Rahematpura S, Ragnini KH, et al

Medicines obtained outside of licensed channels carry significant risks, including unknown purity, incorrect dosing, and absence of medical supervision

In a study of transgenic mice with a Kras G12D mutation which induces PanINs and eventually pancreatic cancer, treatment with exendin-4 increased higher grade PanIN lesions (35, 38)