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To remove ambiguity in the terminology of the ghrelin system, Perell et al

While the drug leaves the bloodstream relatively quickly, the arousal window can remain open for 24 to 72 hours , allowing for much more spontaneity than 4-hour oral pills

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It also explains special fasting requirements for children and people taking GLP-1 medications such as Ozempic or Wegovy

Marketing claims citing a few weeks are promotional copy, not from published research

It has a short half-life in blood of 1.5-3 min due to a high clearance but also activates afferent nerve endings directly before entering the blood