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Change in Blood Pressure as Function of Weight-Change Quartile at 82 Weeks Adding Exenatide to Glucose-Lowering regimen reduces heart failure risk 50,330 patients taking exenatide with insulin and another antidiabetic treatment were 57% less likely to develop heart failure compared to those that took insulin, antidiabetic treatment, but no exenatide (OR 0.43

Most are manageable, especially when treatment starts at a low dose and builds up gradually

Khan N, Mukhtar H

The authors conclude that the renal benefits cannot solely be explained by weight reduction or risk factor reduction, although these may contribute, and the mechanisms of kidney protection are likely to be multifactorial and may include decreased oxidative stress, inflammation and fibrosis in the kidney

Moreover, rare cases of pancreatitis associated with TNF- inhibitors underscore the need for careful evaluation of potential adverse events

Nature 542 , 177185 (2017)