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Insulin resistance refers to a condition where peripheral tissues show decreased sensitivity to insulin actions, requiring larger hormone doses to regulate glucose levels within the normal range

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As described in the results section, the animals included in the experimental design, including the non-androgenized controls, were fed a high-fat diet with 58% kcal from fat, 25.5% from carbohydrates, and 16.4% from proteins (Research Diets, D12331)