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Researchers should validate probe specificity using GSH-depleted controls, such as buthionine sulfoximine (BSO)-treated cells, to confirm that the signal reflects glutathione rather than other intracellular thiols

In the yeast Saccharomyces cerevisiae, the opposite effect is observed: under low zinc conditions, an elevated glutathione concentration is found. So right there, in the abstract, they say that mammals and yeast behave in an opposite fashion when it comes to zinc and glutathione

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Milder JB, Liang LP, Patel M

B., Mihatsch, M., Curschellas, E., Dunn, J

demonstrated that in vitro the development of human myeloid-derived suppressor cells (MDSCs) from CD14+ monocytes cultured in glioma conditioned medium was inhibited by SFN, which may enhance T-cell proliferation ( The molecular principle of how SFN acts in different cell types is as yet only partly understood