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A sustained 14 mmHg reduction in systolic pressure translates to roughly a 40 to 50% reduction in stroke risk and a 20 to 30% reduction in coronary events over the long term

Tirzepatide (Mounjaro, Zepbound) targets two pathways (GLP-1 and GIP), producing greater weight loss in head-to-head studiesroughly 20% body weight loss on tirzepatide vs 15% on semaglutide

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This study suggests that GLP-1 can enhance the function of brown fat, increase heat production in BAT, and reduce body weight in mice by modulating the activity of the sympathetic system through binding with GLP-1R in the center