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GPX4 released from ferroptotic cancer cells functions as a DAMP that suppresses antitumor immunity by engaging the zona pellucida glycoprotein 3 (ZP3) receptor on dendritic cells 101

Extracellular UDP-glucose activates P2Y14 receptor and induces signal transducer and activator of transcription 3 (STAT3) Tyr705 phosphorylation and binding to hyaluronan synthase 2 (HAS2) promoter, stimulating hyaluronan synthesis of keratinocytes

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These coordination behaviors may lead to a decrease in catalytic efficiency (Kawa-mata et al

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10.1111/jcmm.13930 22 FengX.SuredaA.JafariS.MemarianiZ.TewariD.AnnunziataG.et al (2019)