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Similar to autoimmune disorders, mast cells become overzealous in doing their job, releasing histamines and cytokines, like a security alarm constantly going off when theres no real danger

Alharbi et al., 2020)

In chemotherapy, tumor cells are inhibited from taking up zinc from the extracellular space, which may lead to ZD in tumor cells

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however, the difference was not statistically significant

6 The screening model is valuable precisely because it is sensitive, but that sensitivity is also its limitation: many agents that look promising on dermal papilla cells never translate into clinically meaningful regrowth, because a follicle in a dish is insulated from the hormonal, vascular, immune, and mechanical realities of a living scalp