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Considering the substantial role of antioxidant enzymes in maintaining redox homoeostasis of the cells, they are assessed as common biomarkers of the redox status of organisms (Reference Thrond, Bonnefont-Rousselot and Davit-Spraul21)

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Activation of the oxidative stress pathway by HIV-1 Vpr leads to induction of hypoxia-inducible factor 1alpha expression

The mechanisms underlying these effects likely involve glutathione's role in reducing oxidative stress in metabolic tissues, supporting mitochondrial function and energy production, and modulating inflammatory pathways that affect metabolic regulation