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In addition, several markers of metabolic disturbance are improved with tirzepatide use, including dyslipidemia, elevated blood pressure, and impaired renal function

1 (67), and furthermore, this group found that the selective loss of alpha-cell Arx and Dnmt1 expression led to an increase in alpha-cell-derived bihormonal insulin + /glucagon + cells in mouse islets (67)

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the former showed positive results in phase 2 trials [149151], while the latter was discontinued after phase 3 trials [152]