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Independent confirmation comes from placenta-MSC transplantation in ovariectomised rats, where secreted factors activate PI3KFOXO3 to tilt oocyte growth-versus-death decisions [179], and from miR-21-overexpressing bone-marrow MSCs whose transfer of miR-21 targets PTEN/PDCD4, another brake on AKT activity, to suppress granulosa-cell apoptosis [25]

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Arms and Thighs Upper arms often develop significant skin laxity, creating a bat wing appearance thats particularly noticeable in sleeveless clothing problematic for Miamis year-round warm weather

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Some studies show modest improvements in skin texture and fine lines with consistent use

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