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Based on interactions with the FDA, Novo Nordisk has decided to withdraw the file and expects to resubmit the file in the beginning of 2025 with additional relevant data, including data from the once-weekly injectable semaglutide 1.0 mg kidney outcomes trial, FLOW, Novo Nordisk said in in its Q2 2024 financial report

Abstract Introduction: Mechanisms for liraglutide-induced weight loss are poorly understood

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NRF2 and KEAP1 somatic mutations have been shown to correlate with poor clinical outcome in several cancers such as renal cell carcinoma and pancreatic cancer (Jaramillo and Zhang, 2013