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Another computational study that examined the full exomes of 24,248 schizophrenia cases and 97,322 controls observed that some ultra-rare coding variations (URVs) confer a substantial risk for schizophrenia, with odds ratios ranging from 3 to 50 and a p -value of 2.14 10 6

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Thus, the use of this approach allowed to identify an original target, the protein kinase DYRK1B, suggesting that an inhibitor of this protein could present a possible senolytic activity 40